Severe hemolytic exacerbations of Chinese PNH patients infected SARS‐CoV‐2 Omicron

Characteristics of Taiwanese patients of PNH in the international PNH registry

BACKGROUND Paroxysmal nocturnal hemoglobinuria (PNH) is a rare and acquired hematopoietic stem cell disease, with florid clinical presentations. Although this disease has been characterized in the western countries, its clinical and laboratory features in Taiwan have not yet been reported. RESULTS As a part of an international prospective, non-interventional, observational registration trial ...

Classification of severe asthma exacerbations: a proposal.

The intensity of asthma exacerbations may vary from mild to severe. Many studies have demonstrated that the speed at which severe asthma exacerbation (SAE) develops varies among patients. In some asthmatics, the exacerbation comes on very quickly, whereas in others there is a progressive deterioration of clinical, functional and blood gas parameters. Sudden SAE are characterised by their explos...

Omicron Delta Epsilon

Prevalence of chronic kidney disease in Chinese HIV-infected patients.

BACKGROUND To evaluate the prevalence of chronic kidney disease (CKD) in Chinese HIV-infected population. METHODS This was a cross-sectional point prevalence study. All Chinese HIV-infected patients who were followed up in a tertiary referral center in Hong Kong were recruited. Spot urine was saved for each patient to calculate urine protein-to-creatinine ratio (urine P/Cr). Those with urine ...

The PIG-anchoring defect in NK lymphocytes of PNH patients.

Paroxysmal nocturnal hemoglobinuria (PNH) is clinically characterized by intravascular hemolysis, hemoglobinuria, iron deficiency anemia, and venous thrombosis. Pathophysiologically the disease has now been generally accepted as an acquired defect of phosphatidylinositol glycan (PIG)-anchored molecules on the cell surface of bone marrow-derived cells. This defect is functionally characterized b...